In the LymeLight

Freeskier Angeli VanLaanen, 26, is working on a documentary film, called "LymeLight," that follows her professional ski career and her battle with Lyme disease. The film is currently in the fundraising stage and has no debut date yet.


    This month -- May is Lyme awareness month -- VanLaanen is working to raise funds for her movie, and get the message about Lyme disease out there. "I want to create a campaign to raise awareness for Lyme disease," VanLaanen says. "The goal is to educate and inspire through sharing my experience."The documentary is not for profit, VanLaanen says. Ultimately, VanLaanen hopes to return to competitive halfpipe skiing.

Source:
 http://espn.go.com/action/freeskiing/story/
Links: 
Lyme disease : http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002296/

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A Glimpse of Reality: David Jay’s SCAR Project

The SCAR Project is a series of large-scale portraits of young breast cancer survivors shot by fashion photographer David Jay. Primarily an awareness raising campaign, The SCAR Project puts a raw, unflinching face on early onset breast cancer while paying tribute to the courage and spirit of so many brave young women.
Dedicated to the more than 10,000 women under the age of 40 who will be diagnosed this year alone, The SCAR Project is an exercise in awareness, hope, reflection and healing. The mission is three-fold: raise public consciousness of early-onset breast cancer, raise funds for breast cancer research/outreach programs and help young survivors see their scars, faces, figures and experiences through a new, honest and ultimately empowering lens.

Breast cancer is the leading cause of cancer deaths in young women ages 15-40. The SCAR Project participants range from ages 18 to 35, and represent this often overlooked group of young women living with breast cancer. They journey from across America – and the world – to be photographed for The SCAR Project. Nearly 100 so far. The youngest being 18 years old.

 Although Jay began shooting The SCAR Project primarily as an awareness raising campaign, he was not prepared for something much more immediate . . . and beautiful: “For these young women, having their portrait taken seems to represent their personal victory over this terrifying disease. It helps them reclaim their femininity, their sexuality, identity and power after having been robbed of such an important part of it. Through these simple pictures, they seem to gain some acceptance of what has happened to them and the strength to move forward with pride."

Links:
http://www.thescarproject.org/

http://www.thedailymuse.com/health/a-glimpse-of-reality-david-jays-scar-project/
http://www.cbc.ca/passionateeye/episode/baring-it-all.html

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Dr. William Li: Can we eat to starve Cancer ?

Dr. William Li heads the Angiogenesis Foundation, a nonprofit that is re-conceptualizing global disease fighting,  presents a new way to think about treating cancer and other diseases: anti-angiogenesis, preventing the growth of blood vessels that feed a tumor. The crucial first (and best) step: Eating cancer-fighting foods that cut off the supply lines and beat cancer at its own game.

Why you should listen to him:
Many of society’s most devastating diseases -- cancer, cardiovascular disease, diabetes and Alzheimer’s, to name a few -- share a common denominator: faulty Angiogenesis, the body’s growth of new capillary blood vessels. Given excessive or insufficient blood vessel growth, serious health issues arise. While researching under Harvard surgeon Judah Folkman, who pioneered the study of angiogenesis, Li learned how angiogenesis-based medicine helps patients overcome numerous diseases by restoring the balance of blood-vessel growth.

Li co-founded the Angiogenesis Foundation in 1994. The foundation’s Project ENABLE -- a global system that integrates patients, medical experts and healthcare professionals -- democratizes the spread and implementation of knowledge about angiogenesis-based medicines, diet and lifestyle. Some 40,000 physicians have been educated on new treatments, ranging from cancer care to wound care, by the foundation’s faculty of medical experts, and they are bringing new, lifesaving and disease-preventing techniques to people around the world.

"Imagine that one medical advancement held the promise to conquer cancer, perhaps within your lifetime … the potential to also end more than 70 of life's most threatening conditions, affecting one billion people worldwide. This is the promise of angiogenesis, the first medical revolution of the 21st century." - Dr. William Li

Related articles

• Anti-Angiogenic Drugs May Be Effective Against New Subtype Of Ovarian Cancer (medicalnewstoday.com)
• http://www.angio.org/

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Gay Men More Likely to Have Had Cancer

A new study finds that homosexual men are twice as likely as other males to have been diagnosed with and then survive a cancer, shining a light on the unique medical risks that gay people may face. It's not the first time that researchers have noted differences in health risks linked to sexual orientation. Gay men, of course, are at higher risk of becoming infected with HIV, while lesbians may be more likely than heterosexual women to get breast cancer. Both gay men and lesbians have higher rates of tobacco use than the general population, and research has shown that lesbians drink more and are more prone to obesity than other women.

The new study adds to existing knowledge, but "there's a painful dearth of data about lesbian, gay, bisexual and transgender health in general," noted Liz Margolies, executive director of the National LGBT Cancer Network, who's familiar with the new research. In the new study, published online May 9 in Cancer, researchers examined surveys involving more than 122,000 California residents from 2001, 2003 and 2005. Among other things, the surveys asked about sexual orientation and whether the participants had ever been diagnosed with cancer. About 8 percent of the gay men in the group reported having had cancer almost double the rate among the heterosexual and bisexual men surveyed.

Lesbians didn't have a higher rate of cancer than other women, but lesbian cancer survivors were about twice as likely to report that they had fair or poor health compared to heterosexual women. The study can't say whether gays and lesbians are more likely to develop cancer in the first place, since it doesn't include people who have died from the disease or may be too ill to answer questions, stressed study author Ulrike Boehmer, an associate professor of community health sciences at Boston University School of Public Health. Experts already believe that gay men face a higher risk of anal, lung, testicular and immune-system cancers, she said. For their part, lesbians are thought to possibly be at higher risk of breast cancer, perhaps because many of them don't give birth.

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Can Hormone Therapy or the Pill Prevent Brain Aneurysms?

Taking birth control pills or hormone replacement therapy could protect women against brain aneurysms later in life, a new study suggests, although one neurologist questioned the quality of the research. Cerebral aneurysms occur when a blood vessel in the brain weakens and balloons out, potentially leading to a hemorrhagic (or bleeding) stroke if the vessel bursts. These types of aneurysms are more common in women than men, possibly because lower levels of female hormones after menopause play a role in their development, the study authors noted.

Brain aneurysms are more common after the age of 40 and are most likely to burst when people are in their 50s. In the study, Dr. Michael Chen, of Rush University Medical Center, and colleagues interviewed 60 women who had experienced brain aneurysms and asked about their use of birth control pills and hormone replacement therapy, and compared their answers to those from a group of almost 4,700 other women in the general U.S. public. The women who had brain aneurysms were significantly less likely to have taken birth control pills or received hormone replacement therapy, and were also more likely to have entered menopause earlier, according to the report published online May 4 in the Journal of NeuroInterventional Surgery.

Previous research has suggested that taking birth control pills lowers the risk of hemorrhagic (bleeding) stroke in later life. However, women who either begin menstruating at an early age, don't have children, or both, face a higher risk. Because estrogen is important for the repair and maintenance of blood vessel walls, a drop in the levels of the female hormone is believed to be the reason for the increased risk to the structure of these vessels, the study authors noted in background information about the research. However, commenting on the study, neurologist Dr. Cathy Sila said the research is flawed and its conclusions overstated.

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Race Seems to Play Role in Colorectal Cancer Screening

Elderly black and Hispanic Americans are less likely than whites to get colorectal cancer screening, even though Medicare has expanded coverage for screening tests such as colonoscopy and fecal occult blood test, a new study has found. Researchers examined U.S. National Cancer Institute data between 1996 and 2005 to determine rates of colorectal cancer screening among Medicare beneficiaries aged 70 to 89 with no history of any cancer. Blacks were less likely than whites to receive colorectal cancer screening before and after Medicare provided coverage of fecal occult blood test, and after coverage of colonoscopy, according to the University of Texas School of Public Health study.

The investigators also found that Hispanics were less likely than whites to receive colorectal cancer screening after Medicare provided coverage of colonoscopy. The study is published in the current issue of the journal Cancer Epidemiology, Biomarkers & Prevention. "Colorectal cancer screening increased as Medicare coverage expanded. However, screening rates were still low according to recommendations," study author Aricia White, an epidemic service officer at the U.S. Centers for Disease Control and Prevention, said in a news release from the American Association for Cancer Research.

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New Clues to How Gastric Bypass Surgery Combats Diabetes

Gastric bypass surgery has been known to improve blood sugar control, often sending people with type 2 diabetes into remission, but experts have long wondered exactly how that happens. Now, a new study provides some clues. Circulating amino acids linked with insulin resistance decline dramatically in those who have the bypass surgery, the researchers discovered. They compared 10 obese people with diabetes who had the surgery with 11 who lost weight through dieting. "Something happens after gastric bypass that does not happen as much after the diet-induced weight loss," said Dr. Blandine Laferrere, an associate professor of medicine at St. Luke's Roosevelt Hospital Center and Columbia University, both in New York City.

The surgery, which reduces the stomach to the size of a small pouch, also modifies the junction between the stomach and small intestine. It leads to a dramatic reduction in the level of circulating amino acids that have been linked with diabetes. "The fact that gastric bypass results in the remission of diabetes in the majority of patients is not new," said Laferrere. According to background information in the study, 50 percent to 80 percent of diabetes cases go into remission after the surgery. What doctors have been trying to figure out, she said, is why the bypass surgery is so good at making the diabetes disappear. "The diabetes improves almost immediately, before a significant amount of weight loss occurs," she said. "That points out it is something other than the weight loss."

In the new study, the researchers evaluated biochemical compounds involved in metabolic reactions in the participants. Each group had lost about 20 pounds. The investigators found that the bypass patients had much lower levels of amino acids known as branched-chain amino acids, and the amino acids phenylalanine and tyrosine. "Those changes in the amino acids could be implicated in the mechanism of diabetes remission after gastric bypass," Laferrere said. Experts know the amino acids are linked with insulin resistance partly due to animal studies, she said. "If you supplement the diet of rats with branched-chain amino acids, you can induce more insulin resistance," she explained.

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Tissue Analysis May Help Predict Breast Cancer Outcome

An analysis of breast tissue may help doctors better predict outcomes for women with breast cancer, a new study reports. Researchers analyzed what they describe as "highways" of connective tissue in breast cancer tumors, and found that the way collagen fibers the main component of connective tissue are arranged may aid in a patient's diagnosis and help determine treatment. Collagen not only surrounds most body organs and helps provide structure for the body, it also tells cells how to behave, the study authors noted. Normally, a close-up of collagen resembles a jumbled path or a plate of cooked spaghetti.

In the new study, the researchers analyzed tumor cells from 200 patients with invasive breast cancer. The investigators found signs that the collagen began to act differently as the tumors progressed. "We think the cancer cells start to pull on the collagen and straighten it out, forming a track or highway on which the cells can migrate," study senior author Patricia Keely, an associate professor of cell and regenerative biology at the University of Wisconsin-Madison School of Medicine and Public Health, said in a university news release. As the highways became more developed, the prognoses for patients worsened, the study found.

"We have identified a novel collagen-signature system that may become a very useful addition to the tools clinicians use to determine a breast cancer patient's prognosis," Keely explained. The research is published in the March issue of the American Journal of Pathology. Commenting on the study, Dr. Priscilla A. Furth, a professor of oncology and medicine at Georgetown University's Lombardi Comprehensive Cancer Center, described it as an example of "valid basic research." However, "before any new prognostic test can go into practice it must be extensively validated. This publication is a first step that might trigger additional research to examine the utility of this type of analysis in different settings and by different groups," said Furth, who was not involved with the study.

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Gene Therapy Against HIV Not a Proven Cure

Experts are reacting with cautious optimism to the announcement Monday that researchers reconfigured immune cells so that they became resistant to HIV in six patients infected with the virus. But they say the jury is out on whether the technique might ever spell an end to AIDS. The goal is ultimately a cure or what's called a "functional cure" having the body permanently keep HIV at bay but "we're not there yet," stressed Dr. Michael Kolber, professor of medicine and director of the Comprehensive AIDS Program at the University of Miami Miller School of Medicine.

The trial, reported Feb. 28 at a meeting of HIV specialists in Boston, "was a proof-of-principle that they could go in and do this. They demonstrated that the cells stayed in the patients, but the patients were not cured," said Kolber, who was not involved in the new research. Another expert agreed that the treatment's true potential remains uncertain. "If successful, this probably could have wide application, but going from six patients to an entire epidemic is a ways to go," said Dr. Michael Horberg, director of HIV/AIDS at Kaiser Permanente Health Plan and vice chair of the HIV Medicine Association.

"With other successes we've already had, that makes it more promising and people are starting to have a greater vision as to what's possible." However, as Kolber pointed out, this trial was what's known as a phase I trial, which means it was primarily looking at safety, not effectiveness, although investigators do often report on initial effectiveness results at this stage. The idea came from an isolated case that first made headlines in 2009, involving the so-called "Berlin patient." This man, an American AIDS patient living in Germany, was apparently cured after receiving blood cells from a donor who happened to have a rare, natural immunity to HIV.

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Drop in Breast Cancer Among White Women May Have Stalled

Many American women abandoned hormone replacement therapy after a 2002 study found the treatment was tied to higher breast cancer risk. A sharp drop in breast cancer incidence among whites was observed soon after. However, a new study suggests that the 2002-2003 decline in breast cancer incidence among white women did not continue through 2007. The data suggests that the drop in breast cancers linked to women abandoning hormone replacement therapy (HRT) has now bottomed out.

Breast cancer rates among U.S. white women fell by about 7 percent between 2002 and 2003 after the release in 2002 of findings from the Women's Health Initiative study that linked HRT with an increased risk of breast cancer. To examine whether that trend has continued, American Cancer Society and U.S. National Cancer Institute (NCI) researchers reviewed breast cancer data collected from 2000 to 2007 by NCI Surveillance, Epidemiology and End Results (SEER) registries across the country.

The analysis revealed that the sharp decline in breast cancer rates among white women that occurred between 2002 and 2003 did not continue between 2003 and 2007. Instead, breast cancer rates among white women remained relatively stable from 2003 to 2007. "Postmenopausal hormone replacement therapy certainly had accounted for an increase in the incidence of developing a breast cancer. The use of postmenopausal HRT had sharply declined after multiple reports proved this relationship," noted one expert, Dr. Sharon M. Rosenbaum-Smith, a breast cancer specialist and surgeon at the Comprehensive Breast Center at St. Luke's-Roosevelt Medical Center in New York City.

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Smoking During Head & Neck Cancer Therapy Tied to Poor Outcome

Patients with head and neck cancer who continue to smoke while undergoing radiation treatments have a much lower long-term survival rate than those who kick the addiction, researchers have found. In the study of patients with squamous cell carcinoma of the head and neck, 23 percent of 101 patients who continued to smoke were still alive five years after treatment, compared with 55 percent of matched patients in a control group who quit smoking before they began radiation therapy.

In addition, 53 of the patients who continued to smoke suffered cancer recurrence, compared with 40 patients in the control group. The patients who kept smoking also had more treatment-related complications such as the development of scar tissue, hoarseness and difficulty eating. The poorer outcomes for persistent smokers were found both in patients who had radiation alone and in those who had surgery prior to radiation, the study authors noted in the report published in the February issue of the International Journal of Radiation Oncology/Biology/Physics.

"I've always told patients, 'You should really stop smoking,' but I had no tangible evidence to use to convince them that they would be worse off if they continued to smoke," lead author Dr. Allen Chen, residency training program director at the University of California, Davis, School of Medicine, said in a news release from the American Society for Radiation Oncology. "I wanted concrete data to see if smoking was detrimental in terms of curability, overall survival and tolerability of treatment. We showed continued smoking contributed to negative outcomes with regard to all of those," he added.

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Lead Exposure May Raise Blood Pressure in Pregnancy

In pregnant women, even small amounts of lead in the blood may cause significantly higher blood pressure, new research suggests. The study of 285 pregnant women found that about one in four had a lead level higher than about 1 microgram per deciliter (1 mcg/dL) of umbilical cord blood. That's significantly lower than the safety thresholds set by the U.S Centers for Disease Control and Prevention, which recommends taking action to reduce lead exposure when pregnant women or children have a blood lead level of 5 mcg/dL.

Even so, women in the study with lead levels greater than 1 mcg/dL had higher systolic and diastolic blood pressure readings than those with lower lead levels. The average increase was 6.9 mm Hg and 4.4 mm Hg, respectively. Though further research is needed, the findings suggest that pregnant women may be as sensitive to lead toxicity as young children, said the researchers. Prolonged high blood pressure during pregnancy can lead to complications such as preeclampsia or eclampsia, potentially deadly seizures that also can increase a woman's future risk of heart attack.

"We didn't expect to see effects at such low levels of lead exposure, but in fact we found a strong effect," Dr. Lynn Goldman, dean of the George Washington University School of Public Health and Health Services, said in a university news release. The study did not find an association, however, between lead exposure and pregnancy-induced hypertension or preeclampsia.

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Narrowed Leg Arteries Disable Women Faster Than Men: Study

Women coping with peripheral arterial disease (PAD) in the legs appear to lose mobility faster than men, new research reveals. PAD is marked by narrowing and blockages of the peripheral arteries, usually those in the legs and pelvis. The most common symptoms are pain, cramping and tiredness in the leg or hip muscles when walking or climbing stairs symptoms that go away during rest. "The bottom line is that among those with lower extremity PAD, women have faster declines in mobility and functional performance compared to men," said study author Mary M. McDermott, a professor of medicine.

"This may be related to gender differences in calf muscle, as women tend to have less calf muscle compared to men," McDermott added. She and her colleagues report their findinsg in the Feb. 8 issue of the Journal of the American College of Cardiology. Both the researchers and the American Heart Association note that an estimated 8 million American men and women are affected by lower extremity PAD, with disease prevalence being split about equally across genders. To examine whether disease progression differs among men and women, between 2002 and 2009 McDermott and her team tracked the progress of 380 male and female patients with PAD of the legs in the Chicago area.

All the participants were 59 and older. Over a four-year period, annual mobility assessments were conducted during which each patient was asked to complete a quarter mile, six-minute walk, as well as a four-minute speed test, to observe the development of disability. Changes in calf muscle measurements and characteristics were also noted, alongside knee extension strength. Overall, the research team determined that after adjusting for age, women fared more poorly than men over the course of the study. As the study period unfolded, they noted that women ended up walking less per week and had more difficulty walking the quarter-mile.

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Gene Activity May Affect Acute Myeloid Leukemia Outcome

For acute myeloid leukemia patients, overactive genes in their leukemic stem cells (LSC) can translate into a more difficult struggle to overcome their disease and achieve prolonged remission, new research reveals. "In many cancers, specific subpopulations of cells appear to be uniquely capable of initiating and maintaining tumors," the study authors explained in their report. The researchers identified 52 LSC genes that, when highly active, appear to prompt worse outcomes among acute myeloid leukemia (AML) patients.

Between 2005 and 2007, study author Andrew J. Gentles, of Stanford University in Palo Alto, Calif., and colleagues examined gene activity in a group of AML patients as well as healthy individuals. Separate data concerning AML tumors in four groups of patients (totaling more than 1,000) was also analyzed. In one of the patient groups, the investigators found that higher activity levels among 52 LSC genes meant a 78 percent risk of death within a three-year period. This compared with a 57 percent risk of death in the same time frame for AML patients with lower gene activity among these specific "signature" genes.

In another AML patient group, the research team observed that higher gene activity prompted an 81 percent risk for experiencing a disease set-back over three years, compared with just a 48 percent risk among patients with low gene activity. What's more, Gentles and his colleagues found that higher activity among these 52 LSC genes generally meant a poorer response to chemotherapy treatment and lower remission rates.

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