What is Rett Syndrome

What is Rett syndrome?

Rett syndrome is a disorder of brain development that occurs almost exclusively in girls. After 6 to 18 months of apparently normal development, girls with the classic form of Rett syndrome develop severe problems with language and communication, learning, coordination, and other brain functions. 
Early in childhood, affected girls lose purposeful use of their hands and begin making repeated hand wringing, washing, or clapping motions. They tend to grow more slowly than other children and have a small head size (microcephaly). 
Other signs and symptoms can include breathing abnormalities, seizures, an abnormal curvature of the spine (scoliosis), and sleep disturbances.
Researchers have described several variants of Rett syndrome with overlapping signs and symptoms. The atypical forms of this disorder range from a mild type, in which speech is preserved, to a very severe type that has no period of normal development. A form of Rett syndrome called the early-onset seizure variant has most of the characteristic features of classic Rett syndrome, but also causes seizures that begin in infancy.

How common is Rett syndrome?

This condition affects an estimated 1 : 10,000-22,000 females. Groups of the disease have appeared within families and certain geographic regions, including Norway, Sweden, and northern Italy.

Causes, incidence, and risk factors

Rett syndrome occurs almost exclusively in girls and may be misdiagnosed as autism or cerebral palsy.
Studies have linked many Rett syndrome cases to a defect in the methl-CpG-binding protein 2 (MeCP2) gene. This gene is on the X chromosome. Females have two X chromosomes, so even when one has this significant defect, the other X chromosome is normal enough for the child to survive.
Males born with this defective gene do not have a second X chromosome to make up for the problem.
 Therefore, the defect usually results in miscarriage, stillbirth, or very early death.

Symptoms

An infant with Rett syndrome usually has normal development for the first 6 - 18 months. Symptoms range from mild to severe.
Symptoms may include:

• Apraxia [verbal apraxia or dyspraxia, is a speech disorder in which a person has trouble saying what he or she wants to say correctly and consistently. It is not due to weakness or paralysis of the speech muscles (the muscles of the face, tongue, and lips). The severity of apraxia of speech can range from mild to severe.]
• Breathing problems -- problems tend to get worse with stress; breathing is usually normal during sleep and abnormal while awake
• Change in development
• Excessive saliva and drooling
• Floppy arms and legs -- frequently the first sign
• Intellectual disabilities and learning difficulties (assessing cognitive skills in those with Rett syndrome, however, is difficult because of the speech and hand motion abnormalities)
• Scoliosis
  
  
• Shaky, unsteady, or stiff gait; or toe walking
• Seizures
• Slowing head growth beginning at approximately 5 - 6 months of age
• Loss of normal sleep patterns
• Loss of purposeful hand movements; for example, the grasp used to pick up small objects is replaced by repetitive hand motions like hand wringing or constant placement of hands in mouth
• Loss of social engagement
• Ongoing, severe constipation and gastroesophageal reflux (GERD)
• Poor circulation that can lead to cold and bluish arms and legs
• Severe language development problems

NOTE:
Problems in breathing pattern may be the most upsetting and difficult symptom for parents to watch. Why they happen and what to do about them is not well understood. Most experts in Rett syndrome recommend that parents remain calm through an episode of irregular breathing like breath holding. It may help to remind yourself that normal breathing always returns and that your child will become used to the abnormal breathing pattern.

 

Signs and tests

Genetic testing may be done to look for the gene defect associated with the syndrome. However, since the defect is not identified in everyone with the disease, the diagnosis of Rett syndrome is based on symptoms.
There are several different types of Rett syndrome:

• Atypical
• Classical (meets the diagnostic criteria)
• Provisional (some symptoms appear between ages 1 and 3)

Rett syndrome is classified as atypical if:

• It begins early (soon after birth) or late (beyond 18 months of age, sometimes as late as 3 or 4 years old)
• Speech and hand skill problems are mild
• It is appears in a boy (very rare)

 

Treatment

Treatment may include:

• Assistance with feeding and diapering
• Methods to treat constipation and GERD
• Physical therapy to help prevent the hands from contracting
• Weight bearing exercises for those with scoliosis

Supplemental feedings can help those with slowed growth. A feeding tube may be needed if the patient breathes in (aspirates) food. Diets high in calories and fat, as well as nasogastric tube feeds, can help increase weight and height. Weight gain may improve alertness and social interactions.
Medications such as carbamazepine may be used to treat seizures. Other medications or supplements that have been used or studied include:

• Bromocriptine
• Dextromethorphan
• Folate and betaine
• L-carnitine, which may help improve language skills, muscle mass, alertness, energy and quality of life while decreasing constipation and daytime sleepiness
• L-dopa for motor rigidity in later stages of the disease

Stem cell therapy, alone or in combination with gene therapy, is another hopeful treatment.

 

Support Groups

International Rett Syndrome Association - www.rettsyndrome.org

Expectations (prognosis)_

The disease slowly progresses until the patient is a teenager. Then, symptoms may improve. For example, seizures or breathing problems tend to lessen in late adolescence.
Developmental regression or delays vary. Usually, a child with Rett syndrome sits up properly but may not crawl. For those who do crawl, many do so by scooting on their tummy without using their hands.
Similarly, some children walk independently within the normal age range, while others are delayed, don't learn to walk independently at all, or don't learn to walk until late childhood or early adolescence. For those children who do learn to walk at the normal time, some keep that ability for their lifetime, while other children lose the skill.
Life expectancies are not well studied, although survival at least until the mid-20s is likely. The average life expectancy of a girl with Rett syndrome may be mid-40s. Death is often related to seizure, aspiration pneumonia, malnutrition, and accidents.

Calling your health care provider

Call your health care provider if you have any concerns about your child's development, if you notice a lack of normal development with motor or language skills in a child, or if there are associated disorders that need treatment.

Prevention

The likelihood of having another child with Rett syndrome is less than 1%.

Reference:
http://ghr.nlm.nih.gov/condition/rett-syndrome
http://www.ninds.nih.gov/disorders/rett/detail_rett.htm
http://www.nidcd.nih.gov/health/voice/apraxia.html
http://www.rettsyndrome.org/

Selengkapnya →

ABA Therapy Helps Children with Autism

Applied Behavior Analysis (ABA) is based on the idea that by influencing a response associated with a behavior may cause that behavior to be shaped and controlled. 

• ABA is a mixture of psychological and educational techniques that  are utilized based upon the needs of each individual child. Applied Behavior Analysis is the use of behavioral methods to measure behavior, teach functional skills, and evaluate progress.

• Applied Behavior Analysis (ABA) techniques have been proven in many studies as the leading proven treatment and method of choice on treating individuals with autism spectrum disorder at any level. 

• ABA approaches such as discrete trial training (DTT), Pivotal Response Training (PRT), Picture Exchange Communication System (PECS), Self-Management, and a range of social skills training techniques are all critical in teaching children with autism.Ultimately, the goal is to find a way of motivating the child and using a number of different strategies and positive reinforcement techniques to ensure that the sessions are enjoyable and productive.
  
  

• In all ABA programs, the intent is to increase skills in language, play and socialization, while decreasing behaviors that interfere with learning. The results can be profound. Many children with autism who have ritualistic or self-injurious behaviors reduce or eliminate these behaviors.

• They establish eye contact. 
• They learn to stay on task. 
•  Finally the children acquire the ability and the desire to learn and to do well. 
• Even if the child does not achieve a “best outcome” result of normal functioning levels in all areas, nearly all autistic children benefit from intensive ABA programs.

 
Sources:
http://www.ninds.nih.gov/disorders/autism/detail_autism.htm
http://www.brighttots.com/aba_therapy
http://autismlab.ucsd.edu/
http://www.autism.org.uk/
http://www.autism-society.org/site/PageServer
http://www.autisminternationalfoundation.org/

Selengkapnya →